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ReddyLAB
Contact, Events, How to contact the lab:
University of Cambridge Metabolic Research Laboratories
Level 4, Institute of Metabolic Science
Box 289, Addenbrooke's Hospital
Cambridge, CB2 0QQ
United Kingdom
Tel: +44 1223 336792
Fax: +44 1223 330598
E-mail: areddy@cantab.net
, LAB, Music, News, Publications, Reddy , ReddyLAB, Research, Rounded, SetScroll, Some recent papers from our laboratory…
Circadian Clocks in Human Red Blood Cells. (2011)
O’Neill JS & Reddy AB
Nature 469:498–503
O’Neill JS, van Ooijen G, Dixon L, Troein C, Corellou F, Bouget F-Y, Reddy AB*, Millar A*. (2011)
Circadian rhythms persist without transcription in a eukaryote.
Nature 469:554–558
Disruption of peripheral circadian timekeeping in a mouse model of Huntington's disease and its restoration by temporally scheduled feeding. (2010)
Maywood ES, Fraenkel E, McAllister CJ, Wood N, Reddy AB, Hastings MH, Morton AJ.
J Neurosci. 30(30):10199-204.
Proteomic analysis reveals the role of synaptic vesicle cycling in sustaining the suprachiasmatic circadian clock. (2009)
Deery M, Maywood ES, Chesham JC, Sladek M, Karp NA, Green EW, Charles PD, Reddy AB, Kyriacou CP, Lilley KS, Hastings MH
Current Biology, 19(23):2031-6.
Healthy Clock, Healthy Body, Healthy Mind. (2009)
Reddy AB* & O’Neill J
Trends in Cell Biology, 20(1): 36-44.
, Vertical, What do we work on?
1. Metabolic clocks and peroxiredoxins
We recently discovered that biochemical (non-transcriptional) oscillators exist in complex organisms, as illustrated by rhythms in modification of peroxiredoxin proteins. We are working to dissect the mechanisms underlying these novel oscillations, and how they relate to the existing transcriptional feedback oscillator, in various model systems.
Collaborators:
Prof Andrew Millar, University of Edinburgh, UK.
Dr Frank Scheer, Division of Sleep Medicine, Harvard University, USA.
2. Systems Biology of Clocks
We have had a long-standing interest in the application of systems-level tools to address questions about the mammalian clockwork. At present, we are applying a range of techniques (including high-throughput sequencing (RNA-seq/ChIP-seq), proteomics and metabolomics) to address these questions.
Collaborators:
Dr Kathryn Lilley, Cambridge Centre for Proteomics, University of Cambridge.
Dr Julian Griffin, Department of Biochemistry, University of Cambridge.
Dr Daniel Turner, Wellcome Trust Sanger Institute, Hinxton, Cambridge.
3. Dysfunctional clocks – Clinical/Translational studies
How clocks go wrong in disease is a critical question and we are involved in studies on patients that seek to address this using various molecular-genetic approaches.
Collaborators:
Dr Roger Barker, Department of Clinical Neurosciences, University of Cambridge.
, What they're saying about us in the press...
The Scientist:
New circadian timer?
By Jef Akst
http://www.the-scientist.com/news/display/57960/
Reuters:
Ancient body clock keeps all life on time: studies
By Kate Kelland
http://www.reuters.com/article/idUSTRE70P7AY20110126
Deutsche Welle:
Internal clock mechanism found in enzyme present in all life
By Cyrus Farivar
http://www.dw-world.de/dw/article/0,,14797898,00.html
, Why care?, Why do I need to know about biological clocks?
We live in a
Body-clock.org ~
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