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ADMA - Asymmetric dimethylarginine (ADMA) is a naturally occurring component of human blood plasma
Asymmetric dimethylarginine (ADMA) is a naturally occurring component of human blood plasma. It is formed as a metabolic byproduct of continuous protein turnover in all cells of the body. More than one decade ago ADMA was first reported to exert biological effects by inhibiting NO synthesis. Starting with this initial finding, the pathophysiological role of ADMA has subsequently been elucidated in more detail by the collaborative efforts of many groups of researchers throughout the world. Many researchers today agree that ADMA may play a prominent role in the pathogenesis and in the progression of cardiovascular diseases - specifically atherosclerosis. The clinical role of ADMA as a marker of cardiovascular risk can be deduced from an increasing number of clinical studies that have demonstrated the presence of a statistically significant and independent relationship between ADMA and the incidence of major adverse cardiovascular events or death [89]. In Figure 25 diseases have been highlighted in which elevation of ADMA may play an important pathophysiological role.
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